Ƙirƙirar Alurar rigakafin Peptide na Multiepitope akan E Protein na ɗan adam COVID-19: 

Hanyar Immunoinformatics

ShimfiƊda.

Wata sabuwar cuta ta bazu a birnin Wuhan na kasar Sin, a watan Disambar 2019.

A cikin 'yan makonni, Hukumar Lafiya ta Duniya (WHO) ta ba da sanarwar wani sabon labari na coronavirus da aka ayyana a matsayin cutar coronavirus 2019 (COVID-19).

A karshen watan Janairun 2020, WHO ta ayyana barkewar cutar ta "gaggawa da lafiyar jama'a ta kasa da kasa" saboda saurin yaduwar cutar a duniya.

A halin yanzu, babu alluran rigakafi ko maganin da aka yarda da shi don wannan kamuwa da cuta da ke fitowa; don haka, makasudin wannan binciken shine a tsara allurar peptide multiepitope akan COVID-19 ta amfani da tsarin rigakafi.

Hanya.

An yi amfani da fasahohi da yawa waɗanda ke sauƙaƙe haɗakar tsarin rigakafi da tsarin kwatancen genomic don tantance yuwuwar peptides don tsara maganin peptide na tushen T-cell epitope ta amfani da furotin ambulan na 2019-nCoV a matsayin manufa.

Sakamako.

An gano ɗimbin maye gurbi, shigarwa, da gogewa tare da daidaitawa a cikin nau'in COVID-19.

Bugu da kari, an gano peptides goma da ke daure ga ajin MHC na I da MHC ajin II a matsayin 'yan takara masu alƙawarin ƙirƙira rigakafin tare da isassun yawan jama'ar duniya na 88.5% da 99.99%, bi da bi.

Kammalawa.

An tsara alurar rigakafin peptide na tushen T-cell don COVID-19 ta amfani da furotin ambulan azaman makasudin rigakafi.

Duk da haka, maganin da aka tsara cikin sauri yana buƙatar tabbatar da ingancinsa a asibiti don tabbatar da amincinsa da kuma bayanan rigakafi don taimakawa wajen dakatar da wannan annoba kafin ta haifar da mummunar annoba a duniya.

Masu binciken Sudan sun tsara yiwuwar rigakafin COVID-19

A cikin 2020, kafin a samar da allurar rigakafin cutar ta COVID-19, masu bincike a Sudan sun ba da shawarar allurar rigakafin da za ta haifar da martanin rigakafi daga furotin ambulan na kwayar cutar SARS-CoV-2.

A lokacin, masu bincike da yawa suna neman yuwuwar amintattun allurar rigakafin cutar COVID-19, wanda ya fara yaduwa cikin sauri a duniya.

Alurar rigakafin peptide hanya ce mai aminci kuma mai rahusa idan aka kwatanta da sauran nau'ikan rigakafin.

Peptides gajeru ne na amino acid kuma waɗannan amino acid sune tubalan gina jiki na sunadaran, waɗanda ke ɗauke da peptides da yawa.

Epitope shi ne peptide wanda tsarin garkuwar jiki zai iya gane shi.

Allurar rigakafin peptide suna amfani da epitopes daga ɓangaren ƙwayoyin cuta wanda ke haifar da amsawar rigakafi a cikin jiki, a wannan yanayin furotin ambulan, ko furotin E.

Sunan furotin E ya zama wani ɓangare na gashin furotin ("rufin") da ke kewaye da ƙwayar cuta.

Wannan furotin yana taka muhimmiyar rawa a yadda kwayar cutar ke cutar da kwayoyin halitta da kuma yadda take haifar da cututtuka.

Masu binciken a cikin wannan binciken sun yi niyyar tsara maganin rigakafin peptide ta hanyar kwatanta jerin kwayoyin peptides da aka raba tsakanin nau'ikan coronavirus daban-daban, ta amfani da furotin (E) a matsayin manufa.

Da farko sun bincika bayanan bayanai don jerin kwayoyin halitta masu yuwuwar harin peptide.

Bayan haka, sun yi amfani da tsarin kwamfuta da iliminsu game da yadda alluran rigakafi ke motsa martanin rigakafi don gano jerin kwayoyin halitta waɗanda za a iya amfani da su don tsara maganin.

Masu binciken sun sami damar gano adadin peptides da aka raba tsakanin nau'ikan coronavirus daban-daban waɗanda ke da yuwuwar a yi amfani da su azaman rigakafin, amma sun daidaita kan furotin E a matsayin ɗan takarar rigakafin su.

Sun ce sun yi nasarar tsara maganin rigakafin cutar ta COVID-19 ta hanyar yin amfani da jeri na wannan furotin ambulan.

A lokacin, masu binciken sun ce su ne farkon waɗanda suka gano sassan furotin (E) ambulan (peptides) a matsayin masu neman rigakafin COVID-19.

Binciken nasu ya nuna yuwuwar allurar rigakafin furotin, waɗanda ke da aminci, sababbi, araha da kuma ingantacciyar hanyar haɓaka sabuwar rigakafin cutar ta COVID-19. 

Koyaya, ɗan takararsu na rigakafin zai kasance yana buƙatar ƙarin gwaji a cikin yanayin asibiti don tabbatar da lafiya da tasiri.

A cewar tawagar binciken Sudan da ke bayan wannan binciken, alluran rigakafin furotin ba su da tsada don haɓakawa, don haka suna da damar haɓakawa da rarraba su a ƙasashe masu tasowa.